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HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment.

Abstract:

AimsNiacin has potentially favourable effects on lipids, but its effect on cardiovascular outcomes is uncertain. HPS2-THRIVE is a large randomized trial assessing the effects of extended release (ER) niacin in patients at high risk of vascular events.

Methods and results Prior to randomization, 42 424 patients with occlusive arterial disease were given simvastatin 40 mg plus, if required, ezetimibe 10 mg daily to standardize their low-density lipopro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/eht055

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More from this funder
Funding agency for:
Hopewell, J
Grant:
RE/08/004
Medical Research Council More from this funder
British Heart Foundation More from this funder
Cancer Research UK More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
European heart journal Journal website
Volume:
34
Issue:
17
Pages:
1279-1291
Publication date:
2013-05-01
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Source identifiers:
403066

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