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Journal article

Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients

Abstract:

Both phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have been significantly linked to symptom severity in Parkinson's disease (PD) in humans and emerged independently as competing biomarkers for closed-loop deep brain stimulation (DBS). However, the underlying nature of subthalamic PAC is poorly understood and its relationship with transient beta burst-events has not been investigated. To address this, we studied macro- and micro electrode recordings of local field ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.nbd.2019.02.005

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Sub department:
BNDU
Role:
Author
ORCID:
0000-0002-8404-4742
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Role:
Author
ORCID:
0000-0003-0538-5109
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Sub department:
BNDU
Role:
Author
ORCID:
0000-0002-1954-1873
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Funding agency for:
Tinkhauser, G
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Funding agency for:
Meidahl, A
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Funding agency for:
Brown, P
Grant:
MC_UU_12024/1
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Funding agency for:
Brown, P
Grant:
MC_UU_12024/1
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Funding agency for:
Sharott, A
Grant:
MC_UU_12024/1
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Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Disease Journal website
Volume:
127
Pages:
101-113
Publication date:
2019-02-10
Acceptance date:
2019-02-07
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Source identifiers:
971993
Language:
English
Pubs id:
pubs:971993
UUID:
uuid:66733f72-18af-4c9d-848b-223bc961bcf2
Local pid:
pubs:971993
Deposit date:
2019-02-13

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