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Methylome and transcriptome profiling in Myasthenia Gravis monozygotic twins

Abstract:

To identify novel genetic and epigenetic factors associated with Myasthenia gravis (MG) using an identical twins experimental study design.The transcriptome and methylome of peripheral monocytes were compared between monozygotic (MZ) twins discordant and concordant for MG, as well as with MG singletons and healthy controls, all females. Sets of differentially expressed genes and differentially methylated CpGs were validated using RT-PCR for expression and target bisulfite sequencing for methy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jaut.2017.05.005

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Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
82
Pages:
62-73
Publication date:
2017-05-25
Acceptance date:
2017-05-15
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Pmid:
28549776
Language:
English
Keywords:
Pubs id:
1092878
Local pid:
pubs:1092878
Deposit date:
2020-03-12

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