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Chapter 5 Long-Range Regulation of α-Globin Gene Expression

Abstract:

Over the past 20 years, there has been an increasing awareness that gene expression can be regulated by multiple cis-acting sequences located at considerable distances (10-1000 kb) from the genes they control. Detailed investigation of a few specialized mammalian genes, including the genes controlling the synthesis of hemoglobin, provide important models to understand how such long-range regulatory elements act. In general, these elements contain a high density of evolutionarily conserved, tr...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Volume:
61
Pages:
143-173
Publication date:
2008-01-01
DOI:
Source identifiers:
289810
ISBN:
9780123738813
Pubs id:
pubs:289810
UUID:
uuid:67179847-da3a-449d-a598-894ec49f529c
Local pid:
pubs:289810
Deposit date:
2014-09-10

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