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Thesis

Arginine metabolism in cancer and immunity

Abstract:

Amino acid catabolism causing nutritional stress has emerged as a key immune escape mechanism in cancer to suppress tumour-specific lymphocytes. Here, we show that Arginase-2, the enzyme that breaks down arginine, is released in the blood of acute myeloid leukaemia (AML) patients and mouse models to deplete systemic arginine and inhibit T-cell proliferation and effector function, effects that are abrogated by use of Arginase inhibitors. Importantly, we reveal that the genetic reprogra...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
The A.G. Leventis Foundation More from this funder
Medical Research Council More from this funder
Cancer Research UK More from this funder
Wellcome Trust More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:672b0e8f-04cd-420b-9418-6429008afb92
Deposit date:
2019-04-28

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