A mathematical model of cytotoxic and helper T cell interactions in a tumor microenvironment
We develop a mathematical model to examine the role of helper and cytotoxic T cells in an anti-tumour immune response. The model comprises three ordinary differential equations describing the dynamics of the tumour cells, the helper, and the cytotoxic T cells and implicitly accounts for immunosuppressive effects. The aim is to investigate how the anti-tumour immune response varies with the level of infiltrating helper and cytotoxic T cells.
Through a combination of analytical ...Expand abstract
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- Peer reviewed
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- Dritschel et al
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- © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor and Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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