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Journal article

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

Abstract:

The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the respiratory tract via spike glycoprotein binding to angiotensin-converting enzyme (ACE2). Circadian rhythms coordinate an organism's response to its environment and can regulate host susceptibility to virus infection. We demonstrate that silencing the circad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.isci.2021.103144

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Wellcome Trust More from this funder
Publisher:
Cell Press Publisher's website
Journal:
iScience Journal website
Volume:
24
Issue:
10
Article number:
103144
Publication date:
2021-09-15
Acceptance date:
2021-09-13
DOI:
EISSN:
2589-0042
Pmid:
34545347
Language:
English
Keywords:
Pubs id:
1195792
Local pid:
pubs:1195792
Deposit date:
2021-12-20

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