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Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy.

Abstract:

BACKGROUND: Regulatory T cells (Treg) play important roles in preventing autoimmunity, graft-versus host disease and transplant rejection. In rodent transplant models, tolerance induction strategies can induce graft protective CD25CD4 Treg in vivo but therapeutic exploitation of active regulation will more likely depend on protocols that allow generation or selection of regulatory cells ex vivo for use as a cellular therapy. We have used adoptive transfer skin and islet allograft models to i...

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Publication status:
Published

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Publisher copy:
10.1097/tp.0b013e3181806a60

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
86
Issue:
4
Pages:
578-589
Publication date:
2008-08-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
135983

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