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The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.

Abstract:

The autonomic phenotype of congestive cardiac failure is characterised by high sympathetic drive and impaired vagal tone, which are independent predictors of mortality. We hypothesize that impaired bradycardia to peripheral vagal stimulation following high-level sympathetic drive is due to sympatho-vagal crosstalk by the adrenergic co-transmitters galanin and neuropeptide-Y (NPY). Moreover we hypothesize that galanin acts similarly to NPY by reducing vagal acetylcholine release via a receptor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yjmcc.2011.11.016

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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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British Heart Foundation More from this funder
Academy of Medical Sciences More from this funder
National Institutes of Health More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of molecular and cellular cardiology Journal website
Volume:
52
Issue:
3
Pages:
667-676
Publication date:
2012-03-01
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Source identifiers:
221337
Language:
English
Keywords:
Pubs id:
pubs:221337
UUID:
uuid:68d5bd89-edea-44f2-9d96-22218b582891
Local pid:
pubs:221337
Deposit date:
2012-12-19

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