Journal article
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.
- Abstract:
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The autonomic phenotype of congestive cardiac failure is characterised by high sympathetic drive and impaired vagal tone, which are independent predictors of mortality. We hypothesize that impaired bradycardia to peripheral vagal stimulation following high-level sympathetic drive is due to sympatho-vagal crosstalk by the adrenergic co-transmitters galanin and neuropeptide-Y (NPY). Moreover we hypothesize that galanin acts similarly to NPY by reducing vagal acetylcholine release via a receptor...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1016/j.yjmcc.2011.11.016
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Authors
Funding
British Heart Foundation
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Academy of Medical
Sciences
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National Institutes of Health
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of molecular and cellular cardiology Journal website
- Volume:
- 52
- Issue:
- 3
- Pages:
- 667-676
- Publication date:
- 2012-03-01
- DOI:
- EISSN:
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1095-8584
- ISSN:
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0022-2828
- Source identifiers:
-
221337
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:221337
- UUID:
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uuid:68d5bd89-edea-44f2-9d96-22218b582891
- Local pid:
- pubs:221337
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2012
- Notes:
- Copyright © 2011 Elsevier Ltd. Open access under CC BY-NC-ND license. Open Access funded by British Heart Foundation.
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