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Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Abstract:

Fetal growth restriction (FGR) affects 5-10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies implicate KIR and HLA genes in FGR, however, linkage disequilibrium, genetic influence from both parents, and challenges with investigating human pregnancies make the risk alleles and their functional effects difficult to map. Here, we demonstrate that the interaction betwee...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
ORCID:
0000-0001-7722-3956
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Acceptance date:
2022-07-18
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1268614
Local pid:
pubs:1268614
Deposit date:
2022-07-19

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