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Journal article

mwr Xer site-specific recombination is hypersensitive to DNA supercoiling

Abstract:

The multiresistance plasmid pJHCMW1, first identified in a Klebsiella pneumoniae strain isolated from a neonate with meningitis, includes a Xer recombination site, mwr, with unique characteristics. Efficiency of resolution of mwr-containing plasmid dimers is strongly dependent on the osmotic pressure of the growth medium. An increase in supercoiling density of plasmid DNA was observed as the osmotic pressure of the growth culture decreased. Reporter plasmids containing directly repeated mwr, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkp208

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
"University of Oxford", "California State University Fullerton, California, USA"
Department:
Center for Applied Biotechnology Studies,Department of Biological Science,College of Natural Science and Mathematics
Role:
Author
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Institution:
University of Glasgow
Department:
Division of Molecular Genetics,Faculty of Biomedical and Life Sciences
Role:
Author
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Funding agency for:
Trigueros, S
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Funding agency for:
Sherratt, D
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
37
Issue:
11
Pages:
3580-3587
Publication date:
2009-06-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Subjects:
UUID:
uuid:68eb7c61-1440-4826-ad02-d832c8372717
Local pid:
ora:3024
Deposit date:
2009-11-05

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