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Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus

Abstract:
Background Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-terminal dual signal sequence induces high titres of protective antibody after a single dose in mice. A panel of N-terminal signal sequence variants were created to assess the contribution of components of this sequence to transgene expression kinetics of the ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13578-022-00809-3

Authors


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Role:
Author
ORCID:
0000-0001-9456-5712
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-7361-719X
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Publisher:
BioMed Central Publisher's website
Journal:
Cell and Bioscience Journal website
Volume:
12
Issue:
1
Article number:
86
Publication date:
2022-06-11
Acceptance date:
2022-05-09
DOI:
EISSN:
2045-3701
Pmid:
35690803
Language:
English
Keywords:
Pubs id:
1264805
Local pid:
pubs:1264805
Deposit date:
2022-07-04

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