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Protein protein interactions, evolutionary rate, abundance and age

Abstract:

Background: Does a relationship exist between a protein's evolutionary rate and its number of interactions? This relationship has been put forward many times, based on a biological premise that a highly interacting protein will be more restricted in its sequence changes. However, to date several studies have voiced conflicting views on the presence or absence of such a relationship. Results: Here we perform a large scale study over multiple data sets in order to demonstrate that the major rea...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2105-7-128

Authors


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Institution:
University of Oxford
Research group:
Oxford Protein Informatics Group
Department:
Mathematical, Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Oxford Protein Informatics Group
Department:
Mathematical, Physical & Life Sciences Division - Statistics
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC Bioinformatics Journal website
Volume:
7
Pages:
Article: 128
Publication date:
2006-03-05
DOI:
ISSN:
1471-2105
URN:
uuid:69275bff-17ee-4ac4-a0bf-aa8166a7dd42
Local pid:
ora:1808

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