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SARS‐CoV‐2 spike glycoprotein‐binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection

Abstract:

SARS‐CoV‐2 has become a major global challenge. The virus infects host cells using its spike glycoprotein and has significantly higher infectivity and mortality rates among the aged population. Here, based on bioinformatic analysis, I provide evidence that some members of the upper respiratory tract (URT) commensal bacteria express viral spike glycoprotein‐binding proteins. Based on this analysis and available data showing a decline in the population of these bacteria in the elderly, I propos...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/1873-3468.13845

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-6628-944X
Publisher:
Wiley Publisher's website
Journal:
FEBS Letters Journal website
Volume:
594
Issue:
11
Pages:
1651-1660
Publication date:
2020-05-25
Acceptance date:
2020-06-08
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Pmid:
32449939
Language:
English
Keywords:
Pubs id:
1106942
Local pid:
pubs:1106942
Deposit date:
2020-05-27

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