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Journal article

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function.

Abstract:

The use of peptide-human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8(+) T cells has provided a major development in our understanding of their role in controlling viral infections. However, questions remain about the exact function of these cells, particularly in HIV infection. Virus-specific cytotoxic T lymphocytes exert much of their activity by secreting soluble factors such as cytokines and chemokines. We describe here a method ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.192.1.63

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of experimental medicine
Volume:
192
Issue:
1
Pages:
63-75
Publication date:
2000-07-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
25092

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