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Mechanisms of NKG2D ligand regulation

Abstract:

Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8+ αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and cellular proliferation, settings also tightly associated with Warburg metabolism. The molecular events which det...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
O'Callaghan
Oxford college:
Balliol College
Role:
Author
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Division:
MSD
Department:
NDM
Role:
Author

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Supervisor
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Funding agency for:
McCarthy, M
Grant:
G0901998/1
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:69de3276-0b1e-4174-9309-988242468682
Local pid:
ora:7312
Deposit date:
2013-09-16

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