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Thesis

Utrophin upregulation and microRNAs - two avenues of Duchenne muscular dystrophy therapy research

Abstract:

Characterized by the severe progressive wastage of skeletal muscle, Duchenne muscular dystrophy (DMD) is a crippling X-linked recessive disease that is caused by the absence of the protein dystrophin. This thesis aimed to critically evaluate the potential of different therapeutic options to combat this disease. Utrophin is a paralogue of dystrophin. The Fiona mouse is an mdx (dystrophin-deficient) transgenic mouse that overexpresses the full-length utrophin protein in skeletal muscle, and var...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Kay Davies's group
Oxford college:
Exeter College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Bareja, A
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:6a5145e9-7abf-4f86-bb8e-a3284125d99a
Local pid:
ora:5695
Deposit date:
2011-09-16

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