Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response.

Journal article

It is generally considered that myoblasts are unable to prime naive T cell responses without help from professional antigen-presenting cells (APC). However, their ability to present endogenous antigens to previously primed T lymphocytes in the secondary phase of a T cell response has not been well studied. We show here that primary human myoblasts, when stimulated with IFNgamma to express class II MHC, can present an endogenous epitope, probably an acetylcholine receptor (AChR) peptide, to a ...

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Authors: Curnow, J; Corlett, L; Willcox, N; Vincent, A

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 115
• Issue: 1-2
• Pages: 127-134
• Publication date: 2001-04-01
• DOI: 10.1016/s0165-5728(01)00272-7
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Clone Cells; Cells, Cultured; Receptors, Cholinergic; Dose-Response Relationship, Immunologic; Humans; Autoimmunity; Cytokines; Epitopes; Peptide Fragments; Cell Division; CD4-Positive T-Lymphocytes; Myasthenia Gravis; Antigen Presentation; Muscles