Journal article
Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells.
- Abstract:
-
It has been proposed that endogenous H(2)S mediates oxygen sensing in chemoreceptors; this study investigates the mechanisms by which H(2)S excites carotid body type 1 cells. H(2)S caused a rapid reversible increase in intracellular calcium with EC(50) ≈ 6 μM. This [Ca(2+)](i) response was abolished in Ca-free Tyrode. In perforated patch current clamp recordings, H(2)S depolarised type 1 cells from -59 to -35 mV; this was accompanied by a robust increase in [Ca(2+)](i). Voltage clamping at th...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s00424-012-1089-8
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Authors
Bibliographic Details
- Journal:
- Pflugers Archiv : European journal of physiology
- Volume:
- 463
- Issue:
- 5
- Pages:
- 743-754
- Publication date:
- 2012-04-01
- DOI:
- EISSN:
-
1432-2013
- ISSN:
-
0031-6768
- Source identifiers:
-
316379
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:316379
- UUID:
-
uuid:6bbdbbe8-e28d-4347-a171-589ff8ac134f
- Local pid:
- pubs:316379
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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