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HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate.

Abstract:
We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with the strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival.
Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
AIDS (London, England)
Volume:
16
Issue:
15
Pages:
2085-2087
Publication date:
2002-10-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
7520

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