Diastereocontrolled synthesis of hetero- and carbocycles via manganese(III) and copper(II): towards a novel prostaglandin total synthesis

Thesis

The prostaglandins are a unique family of natural products found in all mammalian life, including humans. Their biological significance is profound, and they are responsible for a vast array of bodily functions. This importance, coupled with their low concentration in vivo, has made them attractive targets for total chemical synthesis.

The work herein describes synthetic efforts towards their synthesis using an oxidative radical cyclisation to construct the key [3.3.0]-brid...

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Authors: Docherty, P; Dr. Paul H. Docherty

• Publication date: 2008
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: manganese acetate; cyclisation reactions; natural product synthesis; radical reactions
• Subjects: Natural products; Organic synthesis; Asymmetric catalysis; Heterocyclic chemistry; Synthetic organic chemistry; Catalysis; Organic chemistry