Thesis
Biochemical and functional characterization of the RNA binding protein SAF-A/hnRNP U and investigation of its potential role in mammalian X chromosome inactivation
- Abstract:
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X chromosome inactivation (XCI) is an important mechanism for gene dosage compensation between XY males and XX females during early embryonic development of eutherian mammals. The major regulator of XCI is the long non-coding RNA (lncRNA) X inactive specific transcript (Xist). Xist RNA is believed to recruit epigenetic modifiers and initiate a silencing cascade that alters the chromatin structure and culminates in the transcriptional repression of most genes at the inactive X chromosome (X...
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Funding
Medical Research Council
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Stiftung der Deutschen Wirtschaft
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:6cb30bda-160e-4384-8e69-6f9c41847cb6
- Deposit date:
- 2015-11-01
Terms of use
- Copyright holder:
- Tattermusch, A
- Copyright date:
- 2015
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