Thesis
The role of autophagy in CD8+ T cell immunity
- Abstract:
-
CD8+ T cells form a crucial arm of the adaptive immune system and act as sentinels against infection and cancer. The role of autophagy, a major lysosomal degradation pathway, in T cell biology is currently limited. Here, we show that autophagy is required for naïve CD8+ T cell homeostasis. When the essential autophagy gene Atg7 is deleted in the T cell lineage (T-Atg7-/- mice), mice develop lymphopaenia leading to increased CD8+ T cell homeost...
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Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:6cc5b853-4899-4de2-8924-71f7ee0659a1
- Local pid:
- ora:11786
- Deposit date:
- 2015-07-02
Terms of use
- Copyright holder:
- Daniel Puleston
- Copyright date:
- 2015
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