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Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.

Abstract:

Background.

Influenza A viruses cause occasional pandemics and frequent epidemics. Licensed influenza vaccines that induce high antibody titers to the highly polymorphic viral surface antigen hemagglutinin must be re-formulated and readministered annually. A vaccine providing protective immunity to the highly conserved internal antigens could provide longer-lasting protection against multiple influenza subtypes.

Methods.

We pre... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cid/ciq015

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Hill, A
More from this funder
Funding agency for:
Gilbert, S
National Institute for Health Research More from this funder
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Journal website
Volume:
52
Issue:
1
Pages:
1-7
Publication date:
2011-01-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Source identifiers:
107021

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