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Different modes of variation for each BG lineage suggest different functions.

Abstract:

Mammalian butyrophilins have various important functions, one for lipid binding but others as ligands for co-inhibition of αβ T cells or for stimulation of γẟ T cells in the immune system. The chicken BG homologues are dimers, with extracellular immunoglobulin variable (V) domains joined by cysteines in the loop equivalent to complementarity-determining region 1 (CDR1). BG genes are found in three genomic locations: BG0 on chromosome 2, BG1 in the classical MHC (the BF-BL region) and many BG ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsob.160188

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Caesar, J
Grant:
RG49834
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Funding agency for:
Lea, S
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
6
Issue:
9
Publication date:
2016-09-01
Acceptance date:
2016-08-17
DOI:
ISSN:
2046-2441
Pmid:
27628321
Source identifiers:
646028
Language:
English
Keywords:
Pubs id:
pubs:646028
UUID:
uuid:6d465e9b-fda0-4b4d-b5b9-16cf0ea408fc
Local pid:
pubs:646028
Deposit date:
2016-10-24

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