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Journal article

Filtration of short-wavelength light provides therapeutic benefit in Retinitis Pigmentosa caused by a common rhodopsin mutation.

Abstract:

Purpose: The role of light exposure in accelerating retinitis pigmentosa (RP) remains controversial. Faster degeneration has however been observed in the inferior than superior retina in several forms ("sector" RP), including those caused by the rhodopsin P23H mutation, suggesting a modifying role of incident light exposure in such cases. Rearing of equivalent animal models in complete darkness has been shown to slow the degeneration. Here we investigate the use of red filters as a potent...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1167/iovs.19-26964

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Merton College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biomedical Services
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Arvo Journals Publisher's website
Journal:
Investigative ophthalmology and Visual Science Journal website
Volume:
60
Issue:
7
Pages:
2733–2742
Publication date:
2019-06-01
Acceptance date:
2019-05-31
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
Pmid:
31247114
Source identifiers:
1026758
Language:
English
Keywords:
Pubs id:
pubs:1026758
UUID:
uuid:6d640390-23ff-457d-876f-72c669bc28fb
Local pid:
pubs:1026758
Deposit date:
2019-07-17

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