Journal article
A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
- Abstract:
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Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease expressed in microglia. There is, therefore, a need for authentic, efficient in vitro models to study human microglial pathological mechanisms. Microglia originate from the yolk sac as MYB-independent macrophages, migrating into the developing brain to complete differentiation. Here, we recapitulate microglial ontoge...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.4MB)
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- Publisher copy:
- 10.1016/j.stemcr.2017.05.017
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Authors
Funding
+ Oxford Martin School
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Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
+ Medical Research Council
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Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
+ Oxford Martin School
More from this funder
Grant:
LC0910-004 (James Martin Stem Cell Facility Oxford, W.H., S.A.C.)
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Stem Cell Reports Journal website
- Volume:
- 8
- Issue:
- 6
- Pages:
- 1727-1742
- Publication date:
- 2017-06-06
- Acceptance date:
- 2017-05-15
- DOI:
- ISSN:
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2213-6711
- Source identifiers:
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700430
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:700430
- UUID:
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uuid:6d813413-994f-4a17-a2a4-2f68660f3bd7
- Local pid:
- pubs:700430
- Deposit date:
- 2017-06-26
Terms of use
- Copyright holder:
- Haenseler et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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