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Studying marcomolecular transitions by NMR and computer simulations

Abstract:

Macromolecular transitions such as conformational changes and protein-protein association underlie many biological processes. Conformational changes in the N-terminal domain of the transmembrane protein DsbD (nDsbD) were studied by NMR and molecular dynamics (MD) simulations. nDsbD supplies reductant to biosynthetic pathways in the oxidising periplasm of Gram-negative bacteria after receiving reductant from the C-terminal domain of DsbD (cDsbD). Reductant transfer in the DsbD pathway happens ...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Christina Redfield and Structural Bioinformatics and Computational Biochemistry Unit
Oxford college:
St Catherine's College
Role:
Author
More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:6e4bbe06-fc58-471b-a932-d940fe78b9a5
Local pid:
ora:10615
Deposit date:
2015-03-18

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