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Cholera toxin binds to LewisX and fucosylated glycoproteins play a functional role in human intestinal cell intoxication

Abstract:

Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors via its B subunit (CTB). We have recently shown that in addition to the previously described binding partner ganglioside GM1, CTB binds to fucosylated proteins. Using flow cytometric analysis of primary human jejunal epithelial cells and granulocytes, we now show that CTB binding correlates with expression of the fucosylated Lewis X (LeX) glycan. This binding is competitively blocked by fucosylated olig...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/glycob/cwx086

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Publisher:
Oxford University Press Publisher's website
Journal:
Glycobiology Journal website
Volume:
27
Issue:
12
Pages:
1171–1255
Host title:
Glycobiology
Publication date:
2017-10-27
Acceptance date:
2017-02-07
DOI:
ISSN:
0959-6658 and 1460-2423
Source identifiers:
824715
Pubs id:
pubs:824715
UUID:
uuid:6e80ccd9-78ca-4a96-bc3d-6d8dbd4f0ff3
Local pid:
pubs:824715
Deposit date:
2018-12-17

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