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Journal article

Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature

Abstract:

Oxidative stress plays an important role in aging-related neurodegeneration. This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus endothelial cell–specific human Nox2 overexpression–transgenic (HuNox2Tg) mice to investigate Nox2-derived ROS in brain aging. Compared with young WT mice (3–4 months), aging WT mice (20–22 months) had obvious metabolic disorders and loss of locomotor activity. Aging WT brains had high levels of angiotensin II (Ang II) and ROS production; activati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI125173

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-9090-5326
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
129
Issue:
8
Pages:
3374-3386
Publication date:
2019-07-22
Acceptance date:
2019-05-24
DOI:
ISSN:
1558-8238
Source identifiers:
1034406
Language:
English
Keywords:
Pubs id:
pubs:1034406
UUID:
uuid:6f2e9760-a461-49fb-855c-e6afb76cba6b
Local pid:
pubs:1034406
Deposit date:
2019-07-25

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