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Structure and assembly of calcium homeostasis modulator proteins

Abstract:

The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. Examples include connexin, innexin and pannexin, which form gap junctions and/or bona fide cell surface channels. The most recently identified large-pore channels are the calcium homeostasis modulators (CALHMs), through which ions and ATP permeate in a voltage-dependent manner to control neuronal excitability, taste signaling and pathologies of depression and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41594-019-0369-9

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Role:
Author
ORCID:
0000-0001-6154-6283
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
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Publisher:
Springer Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
27
Pages:
150-159
Publication date:
2020-01-27
Acceptance date:
2019-12-23
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pmid:
31988524
Language:
English
Keywords:
Pubs id:
1084454
Local pid:
pubs:1084454
Deposit date:
2020-02-04

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