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The role of the endoplasmic reticulum stress response following cerebral ischemia

Abstract:
Background Cornu ammonis 3 (CA3) hippocampal neurons are resistant to global ischemia, whereas cornu ammonis (CA1) 1 neurons are vulnerable. Hamartin expression in CA3 neurons mediates this endogenous resistance via productive autophagy. Neurons lacking hamartin demonstrate exacerbated endoplasmic reticulum stress and increased cell death. We investigated endoplasmic reticulum stress responses in CA1 and CA3 regions following global cerebral ischemia, and whether pharmacologi... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1747493017724584

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Oxford college:
Somerville College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
SAGE Publications Publisher's website
Journal:
International Journal of Stroke Journal website
Volume:
13
Issue:
4
Pages:
379-390
Publication date:
2017-08-05
Acceptance date:
2017-07-10
DOI:
EISSN:
1747-4949
ISSN:
1747-4930
Source identifiers:
710851
Keywords:
Pubs id:
pubs:710851
UUID:
uuid:6fac48af-24fa-4a0c-962a-61c1874933ed
Local pid:
pubs:710851
Deposit date:
2017-08-05

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