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Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction.

Abstract:

Hypoxic pulmonary vasoconstriction is unique to pulmonary arteries and serves to match lung perfusion to ventilation. However, in disease states this process can promote hypoxic pulmonary hypertension. Hypoxic pulmonary vasoconstriction is associated with increased NADH levels in pulmonary artery smooth muscle and with intracellular Ca(2+) release from ryanodine-sensitive stores. Because cyclic ADP-ribose (cADPR) regulates ryanodine receptors and is synthesized from beta-NAD(+), we investigat...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m004849200

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
276
Issue:
14
Pages:
11180-11188
Publication date:
2001-04-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
106282
Language:
English
Keywords:
Pubs id:
pubs:106282
UUID:
uuid:6fd5dc23-b7bd-4dae-8526-4c244a8cd57f
Local pid:
pubs:106282
Deposit date:
2012-12-19

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