Journal article
Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction.
- Abstract:
-
Hypoxic pulmonary vasoconstriction is unique to pulmonary arteries and serves to match lung perfusion to ventilation. However, in disease states this process can promote hypoxic pulmonary hypertension. Hypoxic pulmonary vasoconstriction is associated with increased NADH levels in pulmonary artery smooth muscle and with intracellular Ca(2+) release from ryanodine-sensitive stores. Because cyclic ADP-ribose (cADPR) regulates ryanodine receptors and is synthesized from beta-NAD(+), we investigat...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m004849200
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 276
- Issue:
- 14
- Pages:
- 11180-11188
- Publication date:
- 2001-04-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
106282
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106282
- UUID:
-
uuid:6fd5dc23-b7bd-4dae-8526-4c244a8cd57f
- Local pid:
- pubs:106282
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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