Thesis icon

Thesis

Elucidating the role of GBA in the pathology of Parkinson's disease using patient derived dopaminergic neurons differentiated from induced pluripotent stem cells.

Abstract:

Heterozygous mutations in the glucocerebrosidase (GBA) gene represent the most common risk factor for Parkinson’s disease (PD), a disease in which midbrain dopaminergic neurons are preferentially vulnerable. However, the mechanisms underlying this association are still unknown, mostly due to the lack of an appropriate model of study. In this thesis, we aimed at elucidating the role of heterozygous GBA mutations in PD using a specific human induced pluripotent stem cell (h...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Cross College
Role:
Author
More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
More from this funder
Funding agency for:
Ribeiro Fernandes, H
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:7027574c-dda4-4752-9010-4c573bd0b2aa
Local pid:
ora:11487
Deposit date:
2015-05-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP