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L-Carnitine stimulates in vivo carbohydrate metabolism in the Type 1 diabetic heart as demonstrated by hyperpolarized MRI

Abstract:

The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to the metabolic dysfunction in diabetes may be abnormal handling of acetyl and acyl groups by the mitochondria. L-carnitine is responsible for their transfer across the mitochondrial membrane, therefore, supplementation with L-carnitine may provide a route to improve the metabolic state of the diabetic heart. The primary aim of this stud...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/metabo11030191

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Role:
Author
ORCID:
0000-0002-2181-3196
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Role:
Author
ORCID:
0000-0002-6441-0303
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Publisher:
MDPI Publisher's website
Journal:
Metabolites Journal website
Volume:
11
Issue:
3
Article number:
191
Publication date:
2021-03-23
Acceptance date:
2021-03-19
DOI:
EISSN:
2218-1989

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