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Journal article

B cell repertoire dynamics after sequential Hepatitis B vaccination, and evidence for cross-reactive B cell activation

Abstract:
Background: A diverse B cell repertoire is essential for recognition and response to infectious and vaccine antigens. High-throughput sequencing of B cell receptor (BCR) genes can now be used to study the B cell repertoire at great depth, and may shed more light on B cell responses than conventional immunological methods. Here, we use high-throughput BCR sequencing to provide novel insight into B cell dynamics following a primary course of Hepatitis B vaccination. Me... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13073-016-0322-z

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Galson, J
Grant:
CASE studentship
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Funding agency for:
Galson, J
Grant:
CASE studentship
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Funding agency for:
Pollard, A
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Funding agency for:
Pollard, A
Biotechnology and Biological Sciences Research Council More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
Genome Medicine Journal website
Volume:
8
Article number:
68
Publication date:
2016-01-01
Acceptance date:
2016-05-25
DOI:
ISSN:
1756-994X
Source identifiers:
624148
Keywords:
Pubs id:
pubs:624148
UUID:
uuid:7031119c-b4a3-4ab3-88e6-999972f7460f
Local pid:
pubs:624148
Deposit date:
2016-05-26

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