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Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection

Abstract:

To examine the generality of cholinergic involvement in visual memory in primates, we trained macaque monkeys either on an object-in-place scene learning task or in delayed nonmatching-to-sample (DNMS). Each monkey received either selective cholinergic depletion of inferotemporal cortex (including the entorhinal cortex and perirhinal cortex) with injections of the immunotoxin ME20.4-saporin or saline injections as a control and was postoperatively retested. Cholinergic depletion of inferot...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cercor/bhp097

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More from this funder
Funding agency for:
Browning, P
Grant:
G9119577
More from this funder
Funding agency for:
Gaffan, D
Grant:
G9119577
More from this funder
Funding agency for:
Croxson, P
Grant:
071291/Z/03/Z
More from this funder
Funding agency for:
Baxter, M
Grant:
071291/Z/03/Z
Journal:
Cerebral Cortex Journal website
Volume:
20
Issue:
2
Pages:
282-293
Publication date:
2010-02-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Language:
English
Keywords:
Subjects:
UUID:
uuid:70a71d88-da1a-41de-9396-c1e2a4345345
Local pid:
ora:7792
Deposit date:
2014-02-03

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