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Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2/3 trial

Abstract:
Background For HIV-1-infected young people facing lifelong antiretroviral therapy (ART), short cycle therapy with long-acting drugs offers potential for drug-free weekends, less toxicity, and better quality-of-life. We aimed to compare short cycle therapy (5 days on, 2 days off ART) versus continuous therapy (continuous ART). Methods In this open-label, non-inferiority trial (BREATHER), eligible participants were aged 8–24 years, were stable on first-line ef... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2352-3018(16)30054-6

Authors


Contributors

Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Department:
H5 HUMAN GENETICS WT CENTRE
Role:
Contributor
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Grant:
Technology Assessment (projects: 08/53/25
11/136/108
Medical Research Council More from this funder
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Grant:
EuroCoord (FP7/2007/2015
PENTA Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet HIV Journal website
Volume:
3
Issue:
9
Pages:
e421-e430
Publication date:
2016-06-20
DOI:
ISSN:
2352-3018
Source identifiers:
859206
Pubs id:
pubs:859206
UUID:
uuid:70cb5a12-62de-4798-b7fa-1e72c0a9ebb8
Local pid:
pubs:859206
Deposit date:
2018-07-12

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