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Journal article

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Abstract:: Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding macrodomai...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Marjanović, M., Hurtado-Bagès, S., Lassi, M., Valero, V., Malinverni, R., Delage, H., Navarro, M., Corujo, D., Guberovic, I., Douet, J., Gama-Perez, P., Garcia-Roves, P., Ahel, I., Ladurner, A., Yanes, O., Bouvet, P., Suelves, M., Teperino, R., Pospisilik, J., & Buschbeck, M. (2017). MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption. Nature Structural & Molecular Biology.

MLA Style

Marjanović, M., et al. “MacroH2A1.1 Regulates Mitochondrial Respiration by Limiting Nuclear NAD+ Consumption.” Nature Structural & Molecular Biology, Nature Publishing Group, 2017.

Chicago Style

Marjanović, M, S Hurtado-Bagès, M Lassi, V Valero, R Malinverni, H Delage, M Navarro, et al. 2017. “MacroH2A1.1 Regulates Mitochondrial Respiration by Limiting Nuclear NAD+ Consumption.” Nature Structural & Molecular Biology.
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Publisher copy:: 10.1038/nsmb.3481

Authors

+ Marjanović, M More by this author

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Author

+ Hurtado-Bagès, S More by this author

Role:

Author

+ Lassi, M More by this author

Role:

Author

+ Valero, V More by this author

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Author

+ Malinverni, R More by this author

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Author

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Funding

+ Cancer Research UK More from this funder

Grant:

C35050/A22284

+ Wellcome Trust More from this funder

Grant:

101794

+ European Research Council More from this funder

Grant:

682679

Government of Catalonia More from this funder

‘La Caixa’ Foundation More from this funder

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Bibliographic Details

Publisher:: Nature Publishing Group Publisher's website
Journal:: Nature Structural & Molecular Biology Journal website
Publication date:: 2017-10-01
Acceptance date:: 2017-09-13
DOI:: 10.1038/nsmb.3481
EISSN:: 1545-9985
ISSN:: 1545-9993
Pmid:: 28991266

Item Description

Language:: English
Keywords:: Journal Article
Pubs id:: pubs:737098
UUID:: uuid:71710a27-1c31-4e05-89ec-e82a18e9465e
Local pid:: pubs:737098
Source identifiers:: 737098
Deposit date:: 2017-11-15

Terms of use

Copyright date:: 2017

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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