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Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease.

Abstract:

An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whether patients with psoriasis, a common immune-mediated disease of the skin, are enriched for genetic variants that limit the ability of HIV-1 virus to replicate after infection. We analyzed the HLA class I and class II alleles of 1,727 Caucasian psor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002514

Authors


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Foundation for the National Institutes of Health More from this funder
National Institutes of Health More from this funder
Genetic Association Information Network More from this funder
National Psoriasis Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
2
Article number:
e1002514
Publication date:
2012-02-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
321669

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