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Thesis

Control of expression of human snRNA genes

Abstract:

In humans, protein-coding genes and most small nuclear (sn)RNA genes are transcribed by RNA polymerase II (pol II).The carboxy-terminal domain (CTD) of the largest subunit of pol II possesses multiple heptapetide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Phosphorylation of Ser2, Ser5 and Ser7 mediates the recruitment of transcription and RNA processing factors during the transcription cycle. There are notable differences between snRNA genes and protein-coding genes in te...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Murphy laboratory
Oxford college:
Lincoln College
Role:
Author
More by this author
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:7192b270-deda-4501-b0ad-68134f3b3a36
Local pid:
ora:12218
Deposit date:
2015-09-07

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