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Thesis

The dual influence of tumour hypoxia on the activity of a group B oncolytic adenoviurs

Abstract:

Many oncolytic adenoviruses are in clinical development for the treatment of solid tumours and Enadenotucirev (EnAd), a chimeric group B adenovirus, is one leading candidate. Little is known about its activity in hypoxic regions, a feature present in virtually all solid carcinomas and well known to confer resistance to traditional therapies. Hypoxia may account for the long term persistence of adenovirus in tumours and incomplete tumour coverage, as intratumoral and even intravenous virus del...

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Division:
MSD
Department:
Oncology
Department:
University of Oxford
Role:
Author

Contributors

Role:
Supervisor
Cancer Research UK More from this funder
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Funding agency for:
Ambuludi, E
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
UUID:
uuid:71f8249f-510b-4af9-a927-d6d6ae31abac
Deposit date:
2019-09-08

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