The dual influence of tumour hypoxia on the activity of a group B oncolytic adenoviurs

Thesis

Many oncolytic adenoviruses are in clinical development for the treatment of solid tumours and Enadenotucirev (EnAd), a chimeric group B adenovirus, is one leading candidate. Little is known about its activity in hypoxic regions, a feature present in virtually all solid carcinomas and well known to confer resistance to traditional therapies. Hypoxia may account for the long term persistence of adenovirus in tumours and incomplete tumour coverage, as intratumoral and even intravenous virus del...

Expand abstract

Authors: Ambuludi, E

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Oncolytic virus; Adenovirus; Hypoxia