FIT negative clinic as a safety net for low-risk patients with colorectal cancer: impact on endoscopy and radiology utilisation–a retrospective cohort study

Nigam, GB; Meran, L; Bhatnagar, I; Evans, S; Malik, R; Cianci, N; Pakpoor, J; Manganis, C; Shine, B; James, T; Nicholson, BD; East, JE; Palmer, RM

Journal article

FIT negative clinic as a safety net for low-risk patients with colorectal cancer: impact on endoscopy and radiology utilisation–a retrospective cohort study

Abstract:: Background Faecal immunochemical testing (FIT) is recommended by the National Institute for Health and Care Excellence to triage symptomatic primary care patients who have unexplained symptoms but do not meet the criteria for a suspected lower gastrointestinal cancer pathway. During the COVID-19 pandemic, FIT was used to triage patients referred with urgent 2-week wait (2ww) cancer referrals instead of a direct-to-test strategy. FIT-negative patients were assessed and safety netted in a FIT negative clinic.

Methods We reviewed case notes for 622 patients referred on a 2ww pathway and seen in a FIT negative clinic between June 2020 and April 2021 in a tertiary care hospital. We collected information on demographics, indication for referral, dates for referral, clinic visit, investigations and long-term outcomes.

Results The average age of the patients was 71.5 years with 54% female, and a median follow-up of 2.5 years. Indications for referrals included: anaemia (11%), iron deficiency (24%), weight loss (9%), bleeding per rectum (5%) and change in bowel habits (61%). Of the cases, 28% (95% CI 24% to 31%) had endoscopic (15%, 95% CI 12% to 18%) and/or radiological (20%, 95% CI 17% to 23%) investigations requested after clinic review, and among those investigated, malignancy rate was 1.7%, with rectosigmoid neuroendocrine tumour, oesophageal cancer and lung adenocarcinoma.

Conclusion A FIT negative clinic provides a safety net for patients with unexplained symptoms but low risk of colorectal cancer. These real-world data demonstrate significantly reduced demand on endoscopy and radiology services for FIT-negative patients referred via the 2ww pathway.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Nigam, G. B., Meran, L., Bhatnagar, I., Evans, S., Malik, R., Cianci, N., Pakpoor, J., Manganis, C., Shine, B., James, T., Nicholson, B. D., East, J. E., & Palmer, R. M. (2023). FIT negative clinic as a safety net for low-risk patients with colorectal cancer: impact on endoscopy and radiology utilisation–a retrospective cohort study. Frontline Gastroenterology, 15(3), 190–197.

MLA Style

Nigam, G. B., et al. “FIT Negative Clinic as a Safety Net for Low-Risk Patients with Colorectal Cancer: Impact on Endoscopy and Radiology Utilisation–a Retrospective Cohort Study.” Frontline Gastroenterology, vol. 15, no. 3, BMJ Publishing Group, 2023, pp. 190–97.

Chicago Style

Nigam, GB, L Meran, I Bhatnagar, S Evans, R Malik, N Cianci, J Pakpoor, et al. 2023. “FIT Negative Clinic as a Safety Net for Low-Risk Patients with Colorectal Cancer: Impact on Endoscopy and Radiology Utilisation–a Retrospective Cohort Study.” Frontline Gastroenterology 15 (3): 190–97.
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