Thesis icon

Thesis

Understanding the mechanism of Adenovirus endosomal escape

Abstract:

Adenoviruses (AdV) are non-enveloped dsDNA viruses that cause respiratory and gastrointestinal diseases and are commonly used as vaccine and gene therapy vectors. In order to replicate inside a host cell, AdV must first penetrate the endosomal membrane and gain access to the cytosol. A highly conserved amphiphilic alpha helix within AdV protein VI (pVI) has been proposed as the membrane-lytic factor that is necessary for endosomal escape. However, the precise mechanism of endosomal membran...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Role:
Author

Contributors

Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP