Journal article icon

Journal article

Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies

Abstract:
Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3390/vaccines9030262

Authors


More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Expand authors...
Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Volume:
9
Issue:
3
Article number:
262
Publication date:
2021-03-16
Acceptance date:
2021-03-13
DOI:
ISSN:
2076-393X
Language:
English
Keywords:
Pubs id:
1167318
Local pid:
pubs:1167318
Deposit date:
2021-03-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP