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FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.

Abstract:

Recent studies demonstrated a role of sphingosine-1-phosphate (S1P) in the protection against the stress of ischemia/reperfusion (I/R) injury. In experiments reported here, we have investigated the signaling through the S1P cascade by FTY720, a sphingolipid drug candidate displaying structural similarity to S1P, underlying the S1P cardioprotective effect. In ex vivo rat heart and isolated sinoatrial node models, FTY720 significantly prevented arrhythmic events associated with I/R injury inclu...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2009.10.009

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Journal:
Journal of molecular and cellular cardiology
Volume:
48
Issue:
2
Pages:
406-414
Publication date:
2010-02-01
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Source identifiers:
418462

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