Journal article icon

Journal article

Comparing Pooled Peptides with Intact Protein for Accessing Cross-presentation Pathways for Protective CD8+ and CD4+ T Cells

Abstract:

To better understand the mechanisms of intracellular trafficking and presentation of exogenous peptides by antigen-presenting cells (APC), we compared the handling of overlapping 24-mer peptides from HIV Nef either mixed or covalently linked in tandem in one protein. Once internalized, peptides trafficked not only to endosomes but also to cytosol, and activated CD8(+) and CD4(+) T cells. In contrast, whole protein was found to traffic only to the endosomal compartments, and primarily activate...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1074/jbc.M809456200

Authors


More by this author
Role:
Author
ORCID:
0000-0002-7118-3401
Expand authors...
Mary Kinross Charitable Trust More from this funder
Publisher:
American Society for Biochemistry & Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
284
Issue:
14
Pages:
9184-9191
Publication date:
2009-02-04
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
19193636
Source identifiers:
95792

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP