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Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein I

Abstract:

Background: Antibodies targeting variant antigens expressed on the surface of Plasmodium falciparum infected erythrocytes have been associated with protection from clinical malaria. The precise target for these antibodies is unknown. The best characterized and most likely target is the erythrocyte surface-expressed variant protein family Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). Methods: Using recombinant proteins corresponding to five domains of the exp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-7-155

Authors


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Institution:
"Kenya Medical Research Institute Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), Kilifi, Kenya", "University of Oxford"
Research group:
Molecular Parasitology Group
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - NDM John Radcliffe
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Molecular Parasitology Group
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), Kilifi, Kenya"
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute Centre for Geographic Medicine Research Coast (KEMRI-CGMRC), Kilifi, Kenya"
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Molecular Parasitology Group
Role:
Author
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Funding agency for:
Mwangi, T
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Funding agency for:
Mackintosh, C
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Funding agency for:
Marsh, K
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Funding agency for:
Newbold, C
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
7
Article number:
155
Publication date:
2008-08-01
DOI:
ISSN:
1475-2875
Language:
English
Subjects:
UUID:
uuid:7343bdea-b880-4e42-ac75-05c56f3b41cb
Local pid:
ora:3079
Deposit date:
2009-11-25

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