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Investigations into an archaeal RNA polymerase: structure to function analysis

Abstract:

The archaeal RNA polymerase (RNAP) is similar to the eukaryotic RNAP-II in terms of subunit composition and overall protein structure. Despite its similarity, a new archaeal-specific Rpo13 subunit has been identified. Rpo13 occupies a position in the enzyme which, in RNAP-II, is filled by the eukaryotic-specific Rpb5 jaw domain. It has therefore been proposed to contact DNA, where the positively charged C-terminal tail might mediate protein-DNA interactions. Furthermore, analysis of archaeal g...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Prof Stephen D Bell
Oxford college:
Wadham College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:7354996b-5e16-4141-8360-46ab4704c13e
Local pid:
ora:7254
Deposit date:
2013-09-04

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