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Thesis

Understanding the genetic relationship between key effectors of DNA interstrand crosslink repair

Abstract:

With each cell division, our whole genome is duplicated in an error-free and controlled manner. Failure to do so leads to genomic instability. DNA interstrand crosslinks (ICLs) are particularly toxic DNA lesions as when left unrepaired, they are able to block replication producing devastating health conditions such as the genetic syndrome Fanconi Anemia (FA) that predisposes its patients to cancer.

The repair of ICLs is thought to be initiated by the concerted action of multiple nuc...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:73b5cc4e-fcca-43b6-a35c-355ac656a9fc
Deposit date:
2017-07-18

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